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Sérgio Henrique Ferreira
Sérgio Henrique Ferreira (b. April 10, 1934, Franca, São Paulo, Brazil) is a Brazilian physician and pharmacologist noted for the discovery of bradykinin potentiating factor which led to new and widely used anti-hypertension drugs — the ACE inhibitors.
==Biography==
Ferreira received his M.D. from the Faculty of Medicine of Ribeirão Preto of the University of São Paulo (USP) and soon became staff member of the same school, where he is a member of the Department of Pharmacology. His research training in pharmacology initiated in this Department with Prof. Maurício Rocha e Silva, the discoverer of bradykinin. While working on this subject, he discovered a family of peptides present in the venom of a Brazilian snake, ''Bothrops jararaca'', which inhibited kininase activity and strongly potentiated the effects of bradykinin ''in vivo'' and ''in vitro''. This factor was named bradykinin potentiating factor, BPF. In 1968, with the collaboration of Dr. Lewis Joel Greene, from the Brookhaven National Laboratory, U.S., he isolated several pharmacologically active peptides responsible for the activity of BPF. Using those peptides, was demonstrated a general parallelism between bradykinin potentiation and inhibition of Angiotensin I conversion. Subsequently, his group elucidated the structure of the smallest peptide, and using the synthetic pentapeptide, demonstrated its ability to potentiate bradykinin and to inhibit the conversion of angiotensin I in vivo in experimental models of hypertension. His work in this area paved the way for the development of a new class of antihypertensive drugs, the angiotensin converting enzyme (ACE) inhibitors by Squibb scientists. For this work with the Bothrops peptide he received the CIBA Award for Hypertension Research of 1983, together with Drs. E. Ondetti and D. Cushman from Squibb laboratories.
While working in London in the early 1970s with John R. Vane (Nobel prize in Medicine, 1983), he participated in the discovery of the inhibition of the synthesis of prostaglandins by aspirin-like drugs. At that time, he proposed that the mechanism of the analgesic action of nonsteroidal antiinflammatory drugs (NSAIDs) was due to the prevention of pain receptor sensitization which results from an inhibition of the synthesis of prostaglandins. This hypothesis was supported by further work from his laboratory and from many other investigators. His studies on the basic mechanisms involved in the development of inflammatory hyperalgesia led to the discovery that a select class of analgesics like metamizole, in contrast to the classical NSAIDs, are able to counteract the ongoing sensitization of the primary sensory neuron via the stimulation of the arginine/nitric oxide pathway. He recently (December 2008) characterized a phenomenon described as retrograde sensitization of the primary sensory neuron, which emphasizes the importance of the peripheral component of the inflammatory pain. His group made a relevant contribution to the role of bradykinin and of cytokines in the development of inflammatory hyperalgesia. He found that among the cytokines, interleukin 1b mediates the endogenous release of prostaglandins and IL-8 is responsible for the development of the sympathetic hyperalgesia. In this area he described an antagonist of IL-1 that is now being developed as a model for a new class of analgesics.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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